You can now book online, or if you prefer contact us here and our expert team will look after you.

Skinvie account 0 Skinvie cart

Nucleofill Treatment: True Skin Regeneration at Skinvie

Featured In

At a glance

No of Sessions
2-3 Sessions

30 Mins

3-5 Days

Results Duration
6-7 months after the first 90 days

What Is Polynucleotides?

Reveal a new you with the revolutionary power of polynucleotide treatment. Nucleofill, a highly purified polynucleotide derived from salmon, offers a non-filler solution to boost collagen and restore volume loss. Discover the science behind this cutting-edge skin booster, which stimulates natural hydration, the generation of fibroblasts and collagen synthesis. Experience remarkable results addressing various skin concerns, from dark circles to wrinkles, for a rejuvenated and radiant you.

What Are Polynucleotides?

Nucleofill is a non-filler treatment designed to boost collagen and restore volume loss. Polynucleotides are fragmented DNA molecules that, when injected into the skin, attract water and improve blood supply, particularly to collagen-producing cells.
Polynucleotides act as a powerful hydrating agent by drawing water to the skin, enhancing moisture retention. This hydration supports skin regeneration and rejuvenation and results in a plumper and more youthful appearance.
They stimulate the production of essential components like collagen, hyaluronic acid and elastin within the skin’s cells. By promoting the generation of fibroblasts, they play a crucial role in improving skin elasticity and firmness.

What Is Nucleofill Used For?

The efficacy and safety of polynucleotides have been extensively studied and supported by scientific evidence. Clinical research has demonstrated remarkable results in addressing multiple common concerns such as sunken tear troughs and acne scarring.

One single session typically lasts around 30 minutes and 2-3 sessions are recommended, spaced three weeks apart, to achieve optimal outcomes. Pain during treatment is minimal, with slight stinging occurring during injections. Our amazing team will help to keep you comfortable throughout your appointment.

Why Nucleofill Is The Gold Standard

Unlike traditional skin boosters, polynucleotides offer non-filler treatment options for collagen and volume restoration. Their unique properties provide natural-looking results without the need for artificial fillers and we use the best product available for this – Nucleofill.

Polynucleotides are a scientifically advanced and effective approach for treating various skin concerns compared to other aesthetic treatments. Their ability to stimulate the skin’s natural production of essential substances sets them apart from many other treatments.


What To Expect From Your Treatment

Unlike instant results seen with dermal fillers, polynucleotides exhibit distinct behaviour. Transformation occurs at a cellular level taking around 6 weeks (2 sessions 3 weeks apart) to reveal a more refreshed, youthful complexion. You will not see any lumps or overfilling concerns, but no instant boost either. Multiple sessions lead to the ultimate payoff – the skin you have been longing for.


What Concerns Do Polynucleotides Treat?

Dark circles
Sunken tear troughs
Sagging skin under the eyes
Acne scarring
Loss of volume
Wrinkles on the face, neck, inner arms and thighs

The Procedure
Injections into targeted areas with minimal pain. This procedure is approximately 30 minutes long.
The Results
As previously mentioned, this unique treatment takes 90 days for optimal results to materialise.
This is a minimally-disruptive procedure, with no significant downtime required. Our experts recommend that you avoid exercise, saunas, steam rooms, sun beds and hot baths for 24 hours to reduce the risk of bruising and swelling. It is also important to keep the treatment area clean in order to avoid infection, which is why we also recommend avoiding makeup for 24 hours and taking care not to touch your skin.
What Areas Can Be Treated With Nucleofill?
Although Nucleofill can be used to treat practically any area of the body, the most popular are the face and the neck.
How Does Nucleofill Work?
Nucleofill is an injectable biorevitalisation procedure composed of polynucleotides that deeply hydrate, stimulate collagen production, contour and tighten the skin. The polynucleotides work to reduce free radical damage while also moisturising and boosting collagen levels.

Why Choose Skinvie?

We take great pride in our constant dedication to treating each patient as an individual and our fundamental values place a strong emphasis on personalised care. We take great pride in providing specialised, holistic treatments that are tailored to your requirements.

You can rely on our team to transform your skin and achieve your goals. We stand out from the crowd for our commitment to providing superior treatments that guarantee a unique experience and outcomes that are beyond expectations.

This field is for validation purposes and should be left unchanged.
Would highly recommend Dr Anna Puri for aesthetic services.

Alk Time

Dr. Anna Puri is the person to go to! She is so knowledgeable and caring. Plus always has the best treatments available. 100% recommend her!

Raquel Burrows

Dr Anna is fantastic, from start to finish i felt in great hands. My lips are looking better than ever and did even have to top up yet after 3 months. Thank you!

Emily Marroni

Had lip fillers with Dr Anna Puri and I am very happy with the results. My lips look amazing. Cant wait for the Xmas party!

Anna Maria

Amazing doctor! Dr Anna Puri is one of those rare doctors who makes you feel totally at ease by explaining the procedure from start to finish.

Angela Eagles

Dr Anna is a true professional, I always feel in safe hands and the results are truly amazing . I would not trust or think about going to anyone else for my procedures.

Sheena 0’Mahony

Dr Anna makes me feel in really safe hands (anxious Annie over here) she is thorough, professional & informative. Careful & considerate in equal measure. Really pleased with my treatments.


I am so delighted with my skin after seeing Dr Anna! I really struggled with my skin for a long time and couldn’t find anyone with experience who could help me, until I found Dr Anna. She helped me understand my skin as well as treat it through my consultation, and now I’ve finally seen amazing results that people always comment on! I’ve recommended to friends too!

Charlotte Lewis-West

I can’t praise Dr Anna enough. She is a talented doctor who understands and reassures her patients. She explains each treatment with total knowledge, care and professionalism. I wouldn’t hesitate to recommend her services. I feel fortunate to have found her.

Concetta Foat

I have been a client of Dr Anna Puri for quite a few years now and thanks to her skill with Anti-Wrinkle Treatments and more lately Profhilo as well as expert advice on skincare routines my skin has never looked so good. Anna’s approach is a subtle one, she helps me look the best version of me but the crucial factor is I definitely look like me, no one would ever know I have these treatments if I didn’t tell them, they’d just think I won the gene pool lottery!

Mary Gorman

Available Treatments

Make an appointment

Ready to enhance your natural beauty? Click below to book your appointment and start your journey today

Shop Products

Discover the ultimate in medical-grade skincare.

In association with

Accept Cookies

We use cookies to personalise content, provide social media features and to analyse our traffic. We also share information about your use of our site with our social media and analytics partners who may combine it with other information that you’ve provided to them or that they’ve collected from your use of their services. By using this website, you agree to the use of cookies as stipulated in our privacy policy.

Accept Cookies